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Wound repair is a highly complex and dynamic process, including many types of cell-cell interactions and participation of cytokines. It is now clear that Wnt/β-catenin signaling pathway plays an important role in skin wound repair. Calcium/calmodulin-dependent protein kinase IV (CaMKIV) has been recently reported to participate in the regulation of cell proliferation and migration in a number of cell types. In this study, we demonstrated the effects of CaMKIV on skin wound healing in vivo and in vitro. Using CaMKIV knockout mice (CaMKIV(DKO)), we examined the influence of CaMKIV on skin wound healing. Compared with the WT mice, mice lacking CaMKIV exhibited a striking acceleration of wound closure. In vitro, CaMKIV deficiency in WT mouse fibroblasts (FB) leads to augmented scratch wound closure and migration. Conversely, the inhibition of Wnt/β-catenin signaling pathway by SB216763 or overexpression of Dsh can restore the impaired wound repair effects of CaMKIV(DKO) FB. Moreover, both SB216763 and overexpression of Dsh can reverse the enhanced expression of fibronectin in CaMKIV(DKO) FB. Our data suggest that CaMKIV may inhibit Wnt/β-catenin signaling pathway to attenuate wound healing in FB, implying that CaMKIV may act as a

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Product Description

The Traditional Pinch Tongue Rosary is a traditional rosary. They have a gilt colored finish and are crafted out of a patented blend of materials. The pinched part is made from rosary beads made from hand dyed cotton threads.The star shape part of the rosary is made from round silver beads, over an inch in diameter.

These rosaries are made with a precious metal that is electroplated by hand, resulting in a semi-gloss finish. The metal is carefully applied with a vacuum-formed mold, so the finished product is highly durable and resists wear.

The precision-formed metal parts are then assembled with precision-milled wood and wood veneers to create a traditional rosary.

The rosary fastens with a stainless steel spring and clasp, adjustable to fit various sized wrists. A gold plated steel spring keeps your hand on the rosary.

Rosary Sizes Available:

Small – 15 – 18mm

Medium – 20 – 23mm

Large – 26 – 29mm

Each rosary comes with 14″ stainless steel chain

Silver Beads:

Silver Beads are commonly used for rosaries since they are considered a symbol of our Lady. The word “rosary” actually means “rose garden” in Italian.

Rosary Size:

All rosary have a length of 14 inches

The pinched part of the rosary is 18mm wide –