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Non-small-cell lung cancer represents the most common and lethal type of lung cancer. Although novel chemotherapeutic agents have improved the outcome in patients with advanced non-small-cell lung cancer, including a new class of fluoropyrimidines such as 5-fluorouracil-based, gemcitabine, and taxanes, responses continue to be modest. Recent advances in our understanding of the biologic characteristics of tumor cells have led to the development of a number of novel combinations, including cisplatin and a third agent, most commonly docetaxel. Many of the new combinations are being tested in large phase III trials. Combination therapy has the potential to improve efficacy with reduced toxicity by exploiting the different mechanisms of action and combinations of cytotoxic drugs. This article reviews the current status of the management of advanced non-small-cell lung cancer and summarizes the best available data on the role of chemotherapy in this setting.The ability of the mammalian cell to function normally requires the synthesis of ribonucleic acid (RNA) in various parts of the cell. The synthesis of RNA is a complex multi-step process which entails the coordination of several enzymes and other proteins which function to produce, assemble and/or process RNA. Additional proteins may be involved in the biogenesis and/or function of the RNA polymerases.
Polymerase I (also known as Pol I, P110 or P1), is a 190,000 dalton enzyme composed of two polypeptide chains, p40 and p47, which are associated through their amino termini (p40 amino terminal or “ATPase” domain) and carboxy termini (p47 carboxy terminal or “DNA binding” domain). Pol I contains 3.5-4.0 mol of zinc per mole of enzyme. It exists mainly in an active (Polymerase Associated) form. The ATPase and DNA binding domains interact with the 5′ ends of precursor and mature mRNA molecules, increasing the specificity and fidelity of RNA synthesis.
The RNA polymerase II

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