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{PAGE_MESSAGE}Clinical outcomes and cost effectiveness of U.S. commercial insurance coverage for experimental adjuvant therapies for breast cancer.
Evidence indicates that some combination chemotherapy regimens offer benefit for breast cancer patients with node-positive disease, as indicated by improved disease-free survival (DFS) and overall survival (OS) compared with single-agent chemotherapy. The objective of this study was to compare the cost effectiveness and clinical outcomes of experimental adjuvant therapy for breast cancer with that of current standard-of-care chemotherapy for the same indication. We identified women with operable and node-positive breast cancer who underwent adjuvant therapy with one of nine experimental adjuvant regimens (EBRT plus HER2-specific therapy, EBRT plus taxane, EBRT plus gemcitabine, or EBRT plus paclitaxel) with a matched cohort of women who received standard-of-care chemotherapy (anthracycline plus cyclophosphamide, fluorouracil, and taxane) within the same health plan. We compared costs, clinical outcomes (DFS and OS), and cost-effectiveness of the experimental adjuvant therapy regimens with that of standard-of-care chemotherapy for the same indication. After matching, there were 208 cases in each arm. The median duration of follow-up was approximately 5 years (interquartile range, 4.1 to 6.3 years), and the median total follow-up was 5.2 years (interquartile range, 3.4 to 5.8 years) for the whole study cohort. Mean DFS and OS were similar for patients in both treatment groups (EBRT plus HER2-specific therapy, 5.1 years [95% CI, 4.7 to 5.5 years] and 9.2 years [95% CI, 8.7 to 9.7 years]; standard-of-care chemotherapy, 4.9 years [95%
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