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The role of the c-fos protein in the induction of cytochrome P450 (CYP) 3A4 and CYP2B1 gene expression in rat hepatocytes was investigated in the present study. An increase in the c-fos protein was found to occur in the liver of rats exposed to phenobarbital, aryloxyalkanoic acids, and bromobenzene for 20 hr. In our electrophoretic mobility shift assay (EMSA) study using radiolabelled c-fos oligonucleotide probes, the formation of a c-fos-CYP3A4-CYP2B1 gene-specific complex was found to occur specifically in the rat hepatocytes. These findings suggest that the c-fos protein may play a role in the induction of the CYP3A4 and CYP2B1 gene expression by chemical compounds in the rat liver.Osarion’s Galaxy Profile Blog Joined June 2007 United States 3005 Posts Last Edited: 2008-08-23 22:59:25 #1
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