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  – UI.   – iSkysoft Data Recovery Keygen.High-dose chemotherapy and autologous stem cell transplantation for relapsed/refractory multiple myeloma: a meta-analysis of trials with dichotomous results.
To assess the benefits and harms of high-dose chemotherapy (HDC) with autologous stem cell transplantation (ASCT) in patients with relapsed/refractory multiple myeloma (RRMM). We searched PubMed, EMBASE, Cochrane Library, Web of Science, and CINAHL up to April 2015. We identified relevant randomized controlled trials (RCTs) comparing HDC with ASCT to standard care in patients with RRMM. The primary end point was overall survival (OS), while the secondary end points were complete response, OS from randomization, and adverse events. The analysis was performed according to the intention-to-treat principle. The quality of the evidence was rated by GRADE. A priori eligibility criteria included published RCTs comparing HDC with ASCT versus standard care. A total of seven trials involving 1385 patients were included. Six trials used melphalan-containing regimens, and the other one used a regimen with cyclophosphamide. There was no significant difference in complete response (RR 0.97, 95% confidence interval [CI] 0.92-1.01, I(2)=0.0%), and OS (RR 1.06, 95% CI 0.95-1.18, I(2)=0.0%). The pooled event-free survival, progression-free survival, and overall response rates were similar between the two groups (RR 0.94, 95% CI 0.82-1.09, I(2)=0.0%, RR 0.98, 95% CI 0.89-1.08, I(2)=0.0%, and RR 1.01, 95% CI 0.95-1.07, I(2)=0.0%, respectively). There were more serious toxic effects in the HDC group. HDC with ASCT is not superior to the standard care for improving OS and obtaining complete response in patients with RRMM. The quality of the evidence is low.//
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