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.canada John Freund 2012 5th.No preview available -.Mechanism of pancuronium-induced inhibition of neuromuscular transmission.
Single muscle fiber tension was monitored during superfusion of the sciatic nerve with 1-5 microM pancuronium. Block of the end-plate potential (EPP) by 10 microM pancuronium was associated with a three- to sixfold increase in the K+ current necessary for restoring action potentials after each EPP. When the amount of pancuronium was increased from 1 to 5 microM, the recovery time decreased in a dose-related manner, while the postdepolarizing afterpotential was reduced in amplitude and duration. The recovery time was abolished at pancuronium concentrations of greater than 20 microM. The present results support the hypothesis that pancuronium blocks the neurotransmitter release process, and not the presynaptic receptor or Na-channel. The physiological importance of these findings is discussed.Process evaluation of a brief intervention aimed at reducing older adults’ alcohol consumption.
There has been a growing interest in brief intervention (BI) in the alcohol literature. The purpose of the present process evaluation was to assess the feasibility of providing a BI to older adults in primary care. We conducted a randomized trial in an outpatient setting where we randomly assigned older adults (n = 124) to either a BI or a minimal intervention (MI) condition. In the MI, participants were only given information on the relation between alcohol and health. In the BI, participants were given the same information but their attitudes toward alcohol were also assessed. After eight months, we assessed participants’ alcohol consumption using a laboratory measure of the level of alcohol consumption and qualitative interviews about the delivered intervention. Our results showed that 58% of the participants complied with the follow-up procedure. There was no difference in the alcohol consumption of participants in the two groups at 8-month follow-up. However, among those who drank alcohol at baseline, the BI group drank significantly less alcohol than the MI group. The qualitative data showed that participants found it difficult to acknowledge their drinking and to receive BI advice. It is important
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