Erowid Methamphetamine Shake N Bake !!INSTALL!!
Erowid Methamphetamine Shake N Bake !!INSTALL!!
Erowid Methamphetamine Shake N Bake
methamphetamine is an agonist of the serotonin, dopamine, and trace amine (trace amine-associated receptor 1 or taar1) receptors. these receptors have attracted considerable attention in the context of psychostimulant abuse and addiction, particularly trace amine-associated receptors 1 (taar1) and 2 (taar2). [11] taar1 is expressed most prominently in the nervous system, including in the brain and spinal cord, has a low-nanomolar affinity for d-methamphetamine and d-amphetamine, and is thought to be the primary site of action of psychostimulants at the trace amine-associated receptor.
the addictive potential of methamphetamine relates to its ability to directly act on monoamine neurotransmission, particularly through its effects on dopamine and serotonin transporters. the initial use of methamphetamine produces a rush of euphoria, which is followed by a phase of dysphoria and is often described as “like being drunk.” [34] this phase generally lasts one to six hours, with euphoria returning after several hours. the euphoria is similar to the rush produced by other psychostimulants, but the dysphoria is generally more pronounced with methamphetamine than with amphetamines. this phase may be followed by a third phase of lasting euphoria, which can last for several days before the cycle of euphoria and dysphoria is repeated.
stimulation of the dopamine transporters reduces the symptoms of hyperthermia and fatigue and appears to increase the stability of the core body temperature in humans and rats. [38] this may be mediated through the dopamine transporter which has a specific affinity for methamphetamine, having a preference for d-methamphetamine over l-methamphetamine. [35] [36] this affinity for methamphetamine causes dopamine and methamphetamine to preferentially cross the dopamine transporter, causing greater stimulation of dopamine neurons and blocking reuptake of dopamine. similar effects are seen with the serotonin transporter (5-htt) when methamphetamine is co-administered with 5-ht.
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