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Campbell Biology 10th Edition. Biolo-graphia.pdf Free Download. E-book – Campbell Biology 11th Edition Online Reviews, Feedback and User Ratings. Biology A Global Approach 10th Edition Pdf Free, Campbell Biology 10th Edition Pdf Free Download.
Campbell Biology 10th Edition Pdf Free. available on Kindle Unlimited and CreateSpace. Download and read it in just minutes.Role of the epileptogenic foci and of the molecular integrity of the recurrent collateral system in the development of seizures in the CA1 and CA3 regions of the hippocampus.
Results from 32 in vivo intracerebral microdialysis recordings in rats showing focal interictal epileptiform discharges (IEDs) with electrocorticographic (ECoG) and electrocorticography (ECoG) confirmation and from three in vitro experiments investigating the role of CA1 and CA3 epileptogenic foci in the initiation and propagation of focal interictal discharges in the hippocampus are described. Interictal activity was initiated in the CA3 region (n = 23) and in the CA1 region (n = 19), and in both regions, it propagated in a caudo-rostral direction. Following intracerebral kainic acid injections, epileptiform activity originated in the CA3 region (n = 6), the CA1 region (n = 6), and in both regions (n = 5). Spread of interictal discharges into the hippocampus took place in the CA1 region (n = 3) and in the CA3 region (n = 6). Spreading of IEDs into the hippocampus and the dissemination of epileptic discharges from the CA1 region to the CA3 region were observed in only a few cases. The integrity of the recurrent collateral system within and between the sublayers of the CA3 region was necessary for an IED to propagate over this area. Spreading of epileptiform discharges from the CA3 region to the CA1 region depended on the spread of the excitatory input to the CA1 region following IEDs in CA3. IEDs, initiated in the CA3 region, may be able to spread into the CA1 region in the absence of synaptically connected CA1 neurons. It is concluded that the spread of interictal discharges depends on the integrity of the recurrent collateral system.
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